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PF 04449913
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PF 04449913

CAS: 1095173-27-5

Ref. 3D-VTB17327

5mgDiscontinued
10mg
Discontinued
25mgDiscontinued
50mgDiscontinued
100mg
Discontinued

Discontinued product. For inquiries about similar products, please fill out our form or email us at support@cymitquimica.com.


Product Information

Name:
PF 04449913
Synonyms:
  • 1-((2R,4R)-2-(1H-Benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea
  • Glasdegib
  • N-[(2R,4R)-2-(1H-Benzimidazol-2-yl)-1-methyl-4-piperidinyl]-N′-(4-cyanophenyl)urea
  • Urea, N-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methyl-4-piperidinyl]-N′-(4-cyanophenyl)-
Description:

PF 04449913 is a potent inhibitor of the enzyme caspase-3. It has been shown to have long-term efficacy and good tolerability in phase II clinical trials. PF 04449913 interacts with cell factor, a protein that is involved in the regulation of cell growth, differentiation, and apoptosis. This inhibition leads to inhibition of myeloid leukemia cells, which are important for the production of white blood cells and platelets in the body. PF 04449913 also inhibits Toll-like receptor signaling pathways that are activated by microbial products such as lipopolysaccharide (LPS). In vivo models have shown PF 04449913 to be well tolerated at doses up to 150 mg/kg/day and to reduce tumor size in mouse xenografts.

Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
Biosynth
Long term storage:
Notes:

Chemical properties

Molecular weight:
374.45 g/mol
Formula:
C21H22N6O
Purity:
Min. 95%
MDL:
Melting point:
Boiling point:
Flash point:
Density:
Concentration:
EINECS:
Merck:
HS code:

Hazard Info

UN Number:
EQ:
Class:
H Statements:
P Statements:
Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

Inquiry about discontinued product: 3D-VTB17327 PF 04449913

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