PNU112455A hydrochloride
CAS: 21886-12-4
Ref. 3D-WAA88612
| 5mg | To inquire | |
| 10mg | To inquire | |
| 25mg | To inquire | |
| 50mg | To inquire | |
| 100mg | To inquire |
Product Information
PNU112455A hydrochloride is a small-molecule growth factor that is a potent inhibitor of the CDK4/6 enzyme. PNU112455A hydrochloride binds to and dephosphorylates CDK4/6, which inhibits the phosphorylation of Rb by cyclin E and prevents the transition from G1 to S phase in cells. PNU112455A hydrochloride has been shown to inhibit growth in cancer cells such as MDA-MB-231 breast cancer cells, epidermal growth factor receptor (EGFR), and miapaca-2 cells. It appears to have a cell-specific apoptotic effect.
Chemical properties
Technical inquiry about: 3D-WAA88612 PNU112455A hydrochloride
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