Darusentan
CAS: 171714-84-4
Ref. 3D-WGA71484
5mg | Discontinued | ||
10mg | Discontinued | ||
25mg | Discontinued | ||
50mg | Discontinued | ||
100mg | Discontinued |
Product Information
- (2S)-2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid
- (αS)-α-[(4,6-Dimethoxy-2-pyrimidinyl)oxy]-β-methoxy-β-phenylbenzenepropanoic acid
- Benzenepropanoic acid, α-[(4,6-dimethoxy-2-pyrimidinyl)oxy]-β-methoxy-β-phenyl-, (S)-
- Benzenepropanoic acid, α-[(4,6-dimethoxy-2-pyrimidinyl)oxy]-β-methoxy-β-phenyl-, (αS)-
- Hmr-4005
- Lu-135252
Darusentan is a drug that is used to treat chronic heart failure. It is a selective endothelin receptor antagonist, which blocks the binding of endothelin-1 to the receptor and prevents the activation of the receptor. This drug has been shown to be beneficial for patients with congestive heart failure who are not on β-blockers. Darusentan has been shown to reduce systolic pressure in these patients, as well as improve cardiac function, kidney fibrosis and reverse experimental models of kidney disease.