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2-[4-(4-Methylbenzenesulfonyl)piperazin-1-yl]acetic acid hydrochloride
CAS: 1171325-50-0
Ref. 3D-WWB32550
| 1g | 1,016.00 € | ||
| 100mg | 257.00 € |
Product Information
2-[4-(4-Methylbenzenesulfonyl)piperazin-1-yl]acetic acid hydrochloride is a potent, selective inhibitor of the sodium channel Nav1.8. It has been shown to inhibit the function of Nav1.8 in human neurons and rat dorsal root ganglia, which may be useful for the treatment of pain associated with inflammation and neuropathic pain conditions. 2-[4-(4-Methylbenzenesulfonyl)piperazin-1-yl]acetic acid hydrochloride binds to the extracellular domain of Nav1.8 with high affinity. This binding prevents the opening of the channel pore and inhibits voltage gating by blocking sodium ion permeability through the channel pore.
Chemical properties
Technical inquiry about: 3D-WWB32550 2-[4-(4-Methylbenzenesulfonyl)piperazin-1-yl]acetic acid hydrochloride
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