Product Information
2-Benzyl-4-chloropyrimidine is a heterocyclic compound that can be synthesized in three steps from potassium. The reaction pathway starts with the addition of chloroacetic acid to pyrimidine-2,4(1H,3H)-dione and then the intermediate 2-benzylpyrimidine is formed by nucleophilic substitution with an amide. Finally, halogenation of the benzyl group forms 2-benzyl-4-chloropyrimidine. This transformation is due to the fact that pyrimidines are nucleophiles, and chloroacetate is a good leaving group. The substituent on the 4 position of the pyrimidine ring determines whether it will be an amide or a halogenated product.
Chemical properties
Technical inquiry about: 3D-XAA40448 2-Benzyl-4-chloropyrimidine
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