3-Sulfonyl-pyrazolo(1,5-A)pyrimidine
CAS: 1173103-84-8
Ref. 3D-YWB10384
| 5mg | Discontinued | ||
| 10mg | Discontinued | ||
| 25mg | Discontinued | ||
| 50mg | Discontinued | ||
| 100mg | Discontinued |
Product Information
Name:
3-Sulfonyl-pyrazolo(1,5-A)pyrimidine
Synonyms:
- 3-Benzenesulfonyl-5,7-dimethyl-2-methylsulfanylpyrazolo[1,5-a]pyrimidine
- 5,7-Dimethyl-2-(methylthio)-3-(phenylsulfonyl)pyrazolo[1,5-a]pyrimidine
- Pyrazolo[1,5-a]pyrimidine, 5,7-dimethyl-2-(methylthio)-3-(phenylsulfonyl)-
- AVN 211
Description:
3-Sulfonyl-pyrazolo(1,5-A)pyrimidine is a potent inhibitor of ion channels that are selective for potassium and calcium. It is a potential drug candidate for the treatment of epilepsy and other diseases. 3-Sulfonyl-pyrazolo(1,5-A)pyrimidine binds to the extracellular domain of the potassium channel Kv1.2 with high affinity (Ki = 0.3 nM). This binding blocks the channel pore and prevents the passage of ions through it. The inhibition is reversible, which means that 3-sulfonyl-pyrazolo(1,5-A)pyrimidine can be removed from the channel by adding external potassium ions or calcium ions. This compound also inhibits voltage gated calcium channels in a similar manner as it does for potassium channels.
Notice:
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Brand:
Biosynth
Long term storage:
Notes:
Chemical properties
Molecular weight:
333.4 g/mol
Formula:
C15H15N3O2S2
Purity:
Min. 95%
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HS code:
