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FGF-basic is one of 23 known members of the FGF family. Proteins of this family play a central role
during prenatal development and postnatal growth and regeneration of a variety of tissues, by
promoting cellular proliferation and differentiation. FGF-basic is a non-glycosylated heparin binding
growth factor that is expressed in the brain, pituitary, kidney, retina, bone, testis, adrenal gland
liver, monocytes, epithelial cells and endothelial cells. FGF-basic signals through FGFR 1b, 1c, 2c,
3c and 4. Recombinant human FGF-basic is a 17.2 kDa protein consisting of 154 amino acid
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