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1,2,3,4,6-Pentagalloylglucose

1,2,3,4,6-Pentagalloylglucose

CAS 14937-32-7

Ref. BP-BP0001

20mg
100mg
1000mg
201.00 €
348.00 €
880.00 €
Estimated delivery time: ~13 days

Product Information

Name:
1,2,3,4,6-Pentagalloylglucose
Synonyms:
  • Beta-1,2,3,4,6-Pentagalloylglucose
Notes:

Can be supplied from milligrams to grams, up to kilograms.
Except the reference standerd, we can supply this product with 80%~95% for food supplements,  health care products, cosmetics etc.
Inquire for bulk scale. References1, Anti-Cancer, Anti-Diabetic and Other Pharmacologic and Biological Activities of Penta-Galloyl-Glucose
Pharmaceutical Research   September 2009, Volume 26, Issue 9, pp 2066-2080 Abstract1, 2, 3, 4, 6-penta-O-galloyl-β-D-glucose (PGG) is a polyphenolic compound highly enriched in a number of medicinal herbals. Several in vitro and a handful of in vivo studies have shown that PGG exhibits multiple biological activities which implicate a great potential for PGG in the therapy and prevention of several major diseases including cancer and diabetes. Chemically and functionally, PGG appears to be distinct from its constituent gallic acid or tea polyphenols. For anti-cancer activity, three published in vivo preclinical cancer model studies with PGG support promising efficacy to selectively inhibit malignancy without host toxicity. Potential mechanisms include anti-angiogenesis; anti-proliferative actions through inhibition of DNA replicative synthesis, S-phase arrest, and G1arrest; induction of apoptosis; anti-inflammation; and anti-oxidation. Putative molecular targets include p53, Stat3, Cox-2, VEGFR1, AP-1, SP-1, Nrf-2, and MMP-9. For anti-diabetic activity, PGG and analogues appear to improve glucose uptake. However, very little is known about the absorption, pharmacokinetics, and metabolism of PGG, or its toxicity profile. The lack of a large quantity of highly pure PGG has been a bottleneck limiting in vivo validation of cancer preventive and therapeutic efficacies in clinically relevant models.   Anti-Cancer, Anti-Diabetic and Other Pharmacologic and Biological Activities of Penta-Galloyl-Glucose.pdf
analysis-method: HPLC-DAD or/and HPLC-ELSD
botanical-source: several Acer spp., Quercus spp., Rhus spp. and Rubus spp.
identification-method: Mass, NMR


Chemical properties

Molecular weight:
940.681
Formula:
C41H32O26
Purity:
98%

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