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Umbelliferone (UMB), a natural antioxidant, is benzopyrone in nature, and it is present in the fruits of golden apple and bitter orange, UMB has a protective effect on membrane fatty acid composition of liver and kidney as supported by antioxidant and antihyperlipidemic effects of UMB reported earlier as evidenced by improved histopathological changes, hepatic and nephritic markers, indicating recovery from the risk of diabetic complications; UMB has antihyperglycemic effect, UMB at 30 mg/kg of body weight possesses a promising antihyperglycemic effect that is comparable with glibenclamide.[1,2]
Umbelliferone analogues and their potential to be antimutagenic/anticarcinogenic against mutations induced by benzo(a)pyrene, a potent mutagen/carcinogen, and hydrogen peroxide, and for their ability to function as free radical scavengers. 
Umbelliferone attenuates the alteration characteristics of allergic airway inflammation,
Umbelliferone derivatives have antimicrobial properties, and has anti-mutagenic effects induced by 4-nitroquinoline 1-oxide or UV irradiation in E. Coli.[9,10]
Umbelliferone derivatives is a novel class of inhibitors for steroid 5α-reductase.
Umbelliferone has antioxidative effect, the antioxidative effect is dose-dependent up to 100 ug/ml and then levelled off with no further increase in activity. 
Umbelliferone is an intracellular pH-sensitive fluorescent indicator and blood-brain barrier probe.
Umbelliferone, ferulic acid and eugenol are competitive and limonene is a competitive–non-competitive inhibitor of alkaline phosphatase, ferulic acid and umbelliferone are competitive, whereas eugenol and limonene are competitive–non-competitive and uncompetitive inhibitors of acetylcholinesterase, respectively. 
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
analysis-method: HPLC-DAD or/and HPLC-ELSD
botanical-source: Occurs widely in plants including Angelica, Artemisia, Ferula and Ruta spp., Hieracium pilosella, Coronilla varia, Picea abies, Peddiea fischeri, Lepidophyllum cupressiforme, Cymbopogon parkeri, Wikstroemia elliptica, Euphorbia humifusa,
identification-method: Mass, NMR
the mechanisms of action of this molecule may contribute for the development of new drugs for the treatment of asthma.
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