Product correctly added to cart.

discount label


CAS: 1617-53-4

Ref. BP-BP0161

{user_price} € Add to cart
Estimated delivery in United States, on Wednesday 10 Jun 2020

Product Information

Long term storage:
Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.

Amentoflavone and its derivatives as novel natural inhibitors of human Cathepsin B(CatB), CatB is a member of the papain superfamily of cysteine proteases and has been implicated in the pathology of numerous diseases, including arthritis and cancer. [5]
Amentoflavone exhibits potent antifungal activity against several pathogenic fungal strains but has a very low hemolytic effect on human erythrocytes, it induces the accumulation of intracellular trehalose on C. albicans as a stress response to the drug, and disrupts the dimorphic transition that forms pseudo-hyphae during pathogenesis, it has great potential to be a lead compound for the development of antifungal agents.[7]
Amentoflavone has been shown to inhibit tumor metastasis in vivo, amentoflavone treatment reduces experimental tumor metastasis and suggest that such an action is associated with attenuation of tumor invasion, proliferation and angiogenesis.[3]
Amentoflavone has been shown to inhibit tumor metastasis in vivo, inhibits experimental tumor metastasis through a regulatory mechanism involving MMP-2, MMP-9, prolyl hydroxylase, lysyl oxidase, VEGF, ERK-1, ERK-2, STAT-1, NM23 and cytokines in lung tissues of C57BL/6 mice.[4]
Amentoflavone has the inhibition of LPS-induced NO formation, is due to its inhibition of NF-kappaB by blocking degradation, which may be the mechanistic basis of the anti-inflammatory effects of amentoflavone.[2]
Amentoflavone induces breast cancer apoptosis through blockade of fatty acid synthesis.[6]
Amentoflavone, a biflavonoid with antiinflammatory activity, inhibits NF-κB/DNA binding activity potently along with inhibition of degradation of IκBα and NF-κB translocation into nucleus in TNFα-activated A549 cells.[1]
Inquire for bulk scale.
The product could be supplied from milligrams to grams, up to kilograms
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
analysis-method: HPLC-DAD or/and HPLC-ELSD
botanical-source: Metasequoia glyptostroboides, Viburnum prunifolium, Podocarpus gracilior, Garcinia livingstonei, Selaginella willdenowii, Rhus succedanea, Garcinia multiflora, Ginkgo biloba, Cupressocyparis leylandii, Cryptomeria japonica, Amentotaxus formos
identification-method: Mass, NMR
type-of-compound: Flavonoids

Chemical properties

Molecular weight:
Yellow powder

Technical inquiry

Please use instead the cart to request a quotation or an order

If you want to request a quotation or place an order, please instead add the desired products to your cart and then request a quotation or order from the cart. It is faster, cheaper, and you will be able to benefit from the available discounts and other advantages.

Please make sure to include the country code in the phone number. Check Wikipedia to find the country code.

Thank you!

Use of cookies

We use our own and third-party cookies to improve our services and show you advertisements related to your preferences by analyzing your browsing habits. You can get more information in our Cookies Policy .