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Amentoflavone

Amentoflavone

CAS 1617-53-4

Ref. BP-BP0161

20mg
100mg
1000mg
157.00 €
214.00 €
576.00 €
Estimated delivery time: ~13 days

Product Information

Name:
Amentoflavone
Long term storage:
Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.
Notes:

Amentoflavone and its derivatives as novel natural inhibitors of human Cathepsin B(CatB), CatB is a member of the papain superfamily of cysteine proteases and has been implicated in the pathology of numerous diseases, including arthritis and cancer. [5]
Amentoflavone exhibits potent antifungal activity against several pathogenic fungal strains but has a very low hemolytic effect on human erythrocytes, it induces the accumulation of intracellular trehalose on C. albicans as a stress response to the drug, and disrupts the dimorphic transition that forms pseudo-hyphae during pathogenesis, it has great potential to be a lead compound for the development of antifungal agents.[7]
Amentoflavone has been shown to inhibit tumor metastasis in vivo, amentoflavone treatment reduces experimental tumor metastasis and suggest that such an action is associated with attenuation of tumor invasion, proliferation and angiogenesis.[3]
Amentoflavone has been shown to inhibit tumor metastasis in vivo, inhibits experimental tumor metastasis through a regulatory mechanism involving MMP-2, MMP-9, prolyl hydroxylase, lysyl oxidase, VEGF, ERK-1, ERK-2, STAT-1, NM23 and cytokines in lung tissues of C57BL/6 mice.[4]
Amentoflavone has the inhibition of LPS-induced NO formation, is due to its inhibition of NF-kappaB by blocking degradation, which may be the mechanistic basis of the anti-inflammatory effects of amentoflavone.[2]
Amentoflavone induces breast cancer apoptosis through blockade of fatty acid synthesis.[6]
Amentoflavone, a biflavonoid with antiinflammatory activity, inhibits NF-κB/DNA binding activity potently along with inhibition of degradation of IκBα and NF-κB translocation into nucleus in TNFα-activated A549 cells.[1]
Inquire for bulk scale.
The product could be supplied from milligrams to grams, up to kilograms
Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
analysis-method: HPLC-DAD or/and HPLC-ELSD
botanical-source: Metasequoia glyptostroboides, Viburnum prunifolium, Podocarpus gracilior, Garcinia livingstonei, Selaginella willdenowii, Rhus succedanea, Garcinia multiflora, Ginkgo biloba, Cupressocyparis leylandii, Cryptomeria japonica, Amentotaxus formos
identification-method: Mass, NMR
type-of-compound: Flavonoids


Chemical properties

Molecular weight:
538.464
Formula:
C30H18O10
Purity:
98%
Color/Form:
Yellow powder

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