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Chebulagic acid

CAS: 23094-71-5

Ref. BP-BP0338

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Estimated delivery in United States, on Monday 17 Aug 2020

Product Information

Chebulagic acid
Long term storage:
Store in a well closed container, protected from air and light. Put into refrigerate or freeze for long term storage.

Chebulagic Acid is a potent α-glucosidase inhibitor, has anti-hyperglycemic effect .[6,7]
Chebulagic acid , a natural anti-oxidant, shows potent anti-inflammatory effects by suppressing NF-κB and MAPK activation in LPS-stimulated RAW 264.7, a mouse macrophage cell line. [3]
Chebulagic acid and punicalagin have broad-spectrum antiviral activity against viruses that use glycosaminoglycans for entry.[5]
Chebulagic acid can reduce the viral cytopathic effect on rhabdomyosarcoma cells with an IC50 of 12.5 ug/mL, the utilization of the chebulagic acid treatment on mice challenged with a lethal dose of enterovirus 71 is able to efficiently reduce mortality and relieve clinical symptoms through the inhibition of viral replication, suggests that chebulagic acid may represent a potential therapeutic agent to control infections to enterovirus 71.[4]
Chebulagic acid has neuroprotective effect via autophagy induction in SH-SY5Y cells.[8]
Chebulagic acid significantly suppresses the onset and progression of arthritis (CIA) in mice, immune suppression via the induction of TGFbeta and CD4+,CD25+ T cells may represent a new strategy in the development of therapies for managing rheumatoid arthritis and other inflammatory diseases.[2]
Chebulagic acid, isolated from the fruits of Terminalia, it shows potent COX–LOX dual inhibition activity with IC50 values of 15 ± 0.288, 0.92 ± 0.011 and 2.1 ± 0.057 μM for COX-1, COX-2 and 5-LOX respectively, it also shows anti-proliferative activity against HCT-15, COLO-205, MDA-MB-231, DU-145 and K562 cell lines, it induces apoptosis in COLO-205 cell line.[1]
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Whenever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
analysis-method: HPLC-DAD or/and HPLC-ELSD
botanical-source: Tannin derived from divi-divi (fruit of Caesalpinia coriaria) and myrobalans (fruit of Terminalia chebula). Present in Geranium spp.
identification-method: Mass, NMR
type-of-compound: Phenols

Chemical properties

Molecular weight:

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