MLKL (phospho Ser358) rabbit pAb
Ref. EK-ES14935
| 50µl | 188.00 € | ||
| 100µl | 316.00 € |
Product Information
- Mixed lineage kinase domain-like protein
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],
Chemical properties
Technical inquiry about: EK-ES14935 MLKL (phospho Ser358) rabbit pAb
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