Apaf-1 rabbit pAb
Ref. EK-ES4108
| 50µl | 188.00 € | ||
| 100µl | 316.00 € |
Product Information
- APAF1; KIAA0413; Apoptotic protease-activating factor 1; APAF-1
This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
Chemical properties
Technical inquiry about: EK-ES4108 Apaf-1 rabbit pAb
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