Estimated delivery in United States, on Wednesday 17 Jul 2024
Product Information
Name:
P2X3 antagonist 34
Synonyms:
- BLU-5937
CAS:
Description:
P2X3 antagonist 34, a potent, selective, and orally active antagonist, targets the P2X3 homotrimeric receptor, exhibiting IC50s of 25 nM, 92 nM, and 126 nM for human, rat, and guinea pig P2X3 receptors respectively. It shows reduced activity against P2X2/3 heterotrimeric receptors across human, rat, and guinea pig models. Notably, this compound demonstrates a significant anti-tussive effect without altering taste[1].
Brand:
Targetmol
Long term storage:
Notes:
Chemical properties
Molecular weight:
456.48
Formula:
C24H26F2N4O3
Purity:
98%
Color/Form:
Solid
InChI:
InChI=1S/C24H26F2N4O3/c1-14-6-8-30-19(10-15-5-4-7-29(13-15)24(32)33-3)22(28-20(30)9-14)21-17(25)11-16(12-18(21)26)23(31)27-2/h6,8-9,11-12,15H,4-5,7,10,13H2,1-3H3,(H,27,31)/t15-/m0/s1
InChI key:
InChIKey=HHJIZLMOCIYWJF-HNNXBMFYSA-N
SMILES:
CNC(=O)c1cc(F)c(-c2nc3cc(C)ccn3c2C[C@@H]2CCCN(C(=O)OC)C2)c(F)c1
MDL:
Melting point:
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Density:
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EINECS:
Merck:
HS code:
Technical inquiry about: TM-T10560 P2X3 antagonist 34
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