Rhapontigenin

CAS: 500-65-2

Ref. TM-T3776

Product Information

• Name: Rhapontigenin
• Synonyms: Protigenin, 1,3-Benzenediol, 5-[(1E)-2-(3-hydroxy-4-methoxyphenyl)ethenyl]-, 1,3-Benzenediol, 5-[2-(3-hydroxy-4-methoxyphenyl)ethenyl]-, (E)-, 1,3-benzenediol, 5-[(E)-2-(3-hydroxy-4-methoxyphenyl)ethenyl]-, 3,3′,5-Stilbenetriol, 4′-methoxy-, (E)-, 5-[(1E)-2-(3-Hydroxy-4-methoxyphenyl)ethenyl]-1,3-benzenediol, 5-[(E)-2-(3-Hydroxy-4-methoxyphenyl)vinyl]benzene-1,3-diol, 5-[(E)-2-(3-hydroxy-4-methoxyphenyl)ethenyl]benzene-1,3-diol, Pontigenin, Prontigenin, Rhapontin aglycone, Rhapontin genin
• CAS: 500-65-2

Description

Rhapontigenin (Protigenin) is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50: 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens. Rhapontigenin is a natural analog of resveratrol with antioxidant and anti-cancer activity. At higher concentrations, rhapontigenin inhibits the proliferation of HL-60R and HepG2 cancer cell lines (IC50: 48 μM).

• Brand: Targetmol

Chemical properties

• Molecular weight: 258.27
• Formula: C₁₅H₁₄O₄
• Purity: 99.88%
• Color/Form: White Off Grey Crystal Powder
• InChI: InChI=1S/C15H14O4/c1-19-15-5-4-10(8-14(15)18)2-3-11-6-12(16)9-13(17)7-11/h2-9,16-18H,1H3/b3-2+
• InChI key: InChIKey=PHMHDRYYFAYWEG-NSCUHMNNSA-N
• SMILES: COc1ccc(/C=C/c2cc(O)cc(O)c2)cc1O