Globotetraosylceramides (porcine RBC)

CAS: 11034-93-8

Ref. TM-T38048

Product Information

• Name: Globotetraosylceramides (porcine RBC)
• Synonyms: CQH (globoside), Ceramide, 1-O-[O-2-(acetylamino)-2-deoxy-β-<span class="text-smallcaps">D</smallcap>-galactopyranosyl-(1→3)-O-α-<smallcap>D</smallcap>-galactopyranosyl-(1→4)-O-β-<smallcap>D</smallcap>-galactopyranosyl-(1→4)-β-<smallcap>D</span>-glucopyranosyl]-, Cytolipin K, Galnac-1-3-gal-1-4-gal-1-4-glc-cer, Ganglioside GL 4, Ganglioside Gb₄, Gb4 Globoside, Gb4 Globotetraosyl ceramide, Gb4Cer, Gb₄, Gb₄Cer, Gbose4Cer, Globo-N-tetraosylceramide, Globoside (human erythrocytes), Globoside GL-4, Globoside Gb 4, Globoside I, Globosidic acid, Globotetraosyl ceramide, Globotetraosylceramide, Parvovirus B19 receptor, Slt-iiv receptor, Tetrahexosylceramide, VT2vp1 Receptor

Description

Globotetraosylceramides are bioactive neutral glycosphingolipids. They are the major glycolipids in human erythrocytes. They act as receptors for the Shiga toxins Stx1, Stx2, and Stx2e, the cytotoxic protein pierisin-1, and parvovirus B19. Globotetraosylceramides increase the expression of proteins responsible for enamel deposition, including ameloblastin, amelogenin, and enamelin, in dental epithelial cells and activate the ERK and p38 MAPK signaling pathways. Levels of globotetraosylceramides are elevated in fibroblasts from patients with salt and pepper syndrome, a neurocutaneous condition characterized by intellectual disability and hyper- and hypo-pigmented skin. Globotetraosylceramides (porcine RBC) contains a mixture of globotetraosylceramides with variable fatty acyl chain lengths isolated from porcine red blood cells.

• Brand: Targetmol

Chemical properties

• Molecular weight: 1339.7
• Formula: C₆₈H₁₂₆N₂O₂₃(fortetracosanoyl)