P53R3
CAS: 922150-12-7
Ref. TM-T41068
1mg | 74.00 € | ||
5mg | 168.00 € | ||
10mg | 242.00 € | ||
25mg | 402.00 € | ||
50mg | 553.00 € | ||
100mg | 768.00 € | ||
500mg | 1,523.00 € |
Product Information
P53R3 is a potent reactivator of p53, effectively restoring sequence-specific DNA binding to several p53 hot spot mutants, namely p53 R175H, p53 R248W, and p53 R273H. This compound exhibits p53-dependent antiproliferative effects with significantly higher specificity compared to PRIMA-1 and promotes the recruitment of both wild-type p53 and p53 M237I to various target gene promoters. Additionally, P53R3 markedly increases the mRNA, total protein, and cell surface expression of death receptor 5 (DR5), demonstrating its utility in cancer research.
Chemical properties
Technical inquiry about: TM-T41068 P53R3
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