Tafamidis
CAS: 594839-88-0
Ref. TM-T4565
| 5mg | 56.00 € | ||
| 10mg | 92.00 € | ||
| 25mg | 152.00 € | ||
| 50mg | 222.00 € | ||
| 100mg | 345.00 € | ||
| 1ml*10 (DMSO) | 62.00 € |
Product Information
- Fx-1006A
Tafamidis (Fx-1006A) is a kinetic stabilizer of transthyretin (TTR) that prevents amyloidogenesis by wild-type and mutant TTRs. It binds to TTR with negative cooperativity (Kd1: 3 nM; Kd2: 278 nM) to stabilize the TTR dimer-dimer interface and inhibit tetrameric dissociation. Tafamidis stabilizes wild-type and clinically significant V30M and V122I mutant TTR amyloidogenic homotetramers (EC50s: 2.7-3.2 μM) under fibril-promoting, denaturing, and physiological conditions in vitro. It stabilizes TTR heterotetramers containing wild-type and mutant subunits ex vivo in human plasma derived from patients carrying V30M or V1221 mutations when used at a concentration of 7.2 μM. Formulations containing tafamidis have been used for the treatment of familial amyloid polyneuropathy.
Chemical properties
Technical inquiry about: TM-T4565 Tafamidis
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