Product Information
- 2-Pyrrolecarboxylic acid, Minaline
- 1H-Pyrrole-2-carboxylic acid
- 1H-pyrrole-2-carboxylate
- 2-Mialine
- 2-Minaline
- 2-Pyrrolecarboxylic acid
- Minalin
- Minaline
- Nsc 48130
Pyrrole-2-carboxylic acid (Minaline) was first identified as a degradation product of sialic acids, then as a derivative of the oxidation of the D-hydroxyproline isomers by mammalian D-amino acid oxidase. The latter relationship results from the lability of the direct oxidation product, A'-pyrroline-4-hydroxy-2-carboxylic acid, which loses water spontaneously to form the pyrrole. A similar reaction is catalyzed by the more specific allohydroxy-D-proline oxidase of Pseudomonas. In whole animal observations, pyrrole-2-carboxylate (PCA) ' was identified in rat or human urine after administration of the D-isomers of hydroxyproline, a finding ascribable to the action of D-amino acid oxidase. Urinary excretion of N-(pyrrole-2-carboxyl) glycine has been reported in a 5-year-old affected with type II hyperprolinemia; The child has mild developmental delay, recurrent seizures of the grand mal type and EEG alterations.
Chemical properties
Technical inquiry about: TM-T4716 Pyrrole-2-carboxylic acid
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