β-Nicotinamide mononucleotide

CAS: 1094-61-7

Ref. TM-T4721

Product Information

• Name: β-Nicotinamide mononucleotide
• Synonyms: β-NM, 3-(Aminocarbonyl)-1-(5-O-phosphonato-beta-D-ribofuranosyl)pyridinium, 3-Carbamoyl-1-β-<span class="text-smallcaps">D</span>-ribofuranosylpyridinium hydroxide, 5′-phosphate, inner salt, 3-carbamoyl-1-(5-O-phosphonopentofuranosyl)pyridinium, 3-carbamoyl-1-[5-O-(hydroxyphosphinato)-beta-D-ribofuranosyl]pyridinium, NMN, NMN (mononucleotide), Nicotinamide mononucleotide, Nicotinamide ribonucleoside 5′-phosphate, Nicotinamide ribonucleotide, Nicotinamide ribotide, Pyridinium, 3-(aminocarbonyl)-1-(5-O-phosphono-beta-D-ribofuranosyl)-, inner salt, Pyridinium, 3-(aminocarbonyl)-1-(5-O-phosphono-β-<span class="text-smallcaps">D</span>-ribofuranosyl)-, hydroxide, inner salt, Pyridinium, 3-(aminocarbonyl)-1-(5-O-phosphono-β-<span class="text-smallcaps">D</span>-ribofuranosyl)-, inner salt, Pyridinium, 3-carbamoyl-1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-, hydroxide, 5′-(dihydrogen phosphate), inner salt, coenzyme NMN, β-<span class="text-smallcaps">D</span>-NMN, β-NMN
• CAS: 1094-61-7

Description

β-Nicotinamide mononucleotide (β-NM) is an important intermediate metabolite in the nicotinate and nicotinamide metabolism pathway. Mammals predominantly use nicotinamide rather than nicotinic acid as a precursor for NAD biosynthesis. Instead of the deamidation to nicotinic acid, nicotinamide is directly converted to β-Nicotinamide mononucleotide by nicotinamide phosphoribosyltransferase (NAMPT, EC 2.4.2.12). The enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT, EC 2.7.7.1), which is a member of the nucleotidyltransferase alpha/beta-phosphodiesterase superfamily, catalyzes the reaction β-Nicotinamide mononucleotide + ATP <=>Nicotinamide adenine dinucleotide (NAD) + PPi, representing the final step in the biosynthesis of NAD. NAD is a molecule that plays a fundamental role as a cofactor in cellular redox reactions. Thus β-Nicotinamide mononucleotide is an important metabolite for the maintenance of normal NAD biosynthesis. Circulating β-Nicotinamide mononucleotide levels may play an important role in regulating cell function in physiological and pathophysiological conditions.

• Brand: Targetmol

Chemical properties

• Molecular weight: 334.22
• Formula: C₁₁H₁₅N₂O₈P
• Purity: 100%
• Color/Form: Solid