Product Information
- Dabcyl-(Gamma-Abu)-Pqgl-E(Edans)Ak-Nh2
- Dabcyl-Gamma-Abu-Pro-Gln-Gly-Leu-Glu(Edans)-Ala-Lys-Nh2
- Dabcyl-Gaba-Pqgl-E(Edans)-Ak-Nh2
- Dabcyl-Gaba-Pro-Gln-Gly-Leu-Glu(Edans)-Ala-Lys-Nh2
- Dabcyl-(G-Abu)-Pqgl-E(Edans)Ak-Nh2
- Dabcyl-(G-Abu)-Pro-Gln-Gly-Leu-Glu(Edans)-Ala-Lys-Nh2
- Tno211
TNO211 is a bioactive peptide that functions as a highly soluble fluorogenic substrate for select Matrix Metalloproteinases (MMPs)-specifically MMP-2, 8, 12, 13, and 14. Incorporating a cleavable Gly-Leu bond and an EDANS/DABCYL fluorophore/quencher pair, TNO211 enables sensitive detection of MMP activity through fluorescence assays, with an absorption/emission profile at 340/490 nm. It is particularly effective in analyzing MMPs in culture media from endothelial cells as well as untreated synovial fluid from patients, highlighting its utility in investigations of MMP-associated cellular behaviors, including proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.
Chemical properties
Technical inquiry about: TM-T80242 TNO211
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