Product Information
- 1-AG
- (all-Z)-(±)-2,3-Dihydroxypropyl 5,8,11,14-eicosatetraenoate
- 1-Arachidonoylglycerol
- 1-Arachidonylglycerol
- 1-Monoarachidin
- 1-Monoarachidonoyl-rac-glycerol
- 5,8,11,14-Eicosatetraenoic acid, 2,3-dihydroxypropyl ester, (all-Z)-
- 5,8,11,14-eicosatetraenoic acid, 2,3-dihydroxypropyl ester, (5Z,8Z,11Z,14Z)-
2-Arachidonoylglycerol (2-AG) is identified as a more potent endogenous cannabinoid ligand compared to its analogue, 1-Arachidonoylglycerol (1-AG), exhibiting 10 to 100 times the ligand binding affinity and agonist activity at the CB1 receptor, thus making it a natural ligand. However, 2-AG's chemical instability leads to rapid isomerization to 1-AG (also referred to as 1(3)-AG) both in vitro and in vivo. This isomerization process, where 1-AG becomes a frequent contaminant in synthetic 1-AG preparations, significantly decreases their cannabinergic potency. Furthermore, 1-AG is characterized as a weak CB1 receptor agonist with potential for other pharmacological effects.
Chemical properties
Technical inquiry about: TM-T84599 1-Arachidonoyl Glycerol
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