Syk Inhibitor II hydrochloride
CAS: 2490508-82-0
Ref. TM-T9543
| 1mg | 40.00 € | ||
| 5mg | 77.00 € | ||
| 10mg | 129.00 € | ||
| 25mg | 211.00 € | ||
| 50mg | 332.00 € | ||
| 100mg | 530.00 € | ||
| 1ml*10 (DMSO) | 84.00 € |
Product Information
The impact of spleen tyrosine kinase (Syk) signaling might be prominent in lupus because (i) Syk is a shared downstream signaling molecule among circulating immune complex, LPS, and (1→3)-β-D-glucan (BG), and (ii) all of these factors are detectable in the serum of Fc gamma receptor IIb-deficient (FcgRIIb-/-) mice with sepsis. Syk inhibition downregulated several inflammatory pathways in FcgRIIb-/- macrophages activated with BG + LPS suggesting the potential anti-inflammatory impact of Syk inhibitors in lupus. Indeed, administration of a Syk inhibitor prior to cecal ligation and puncture (CLP) sepsis in FcgRIIb-/- mice reduced baseline lupus-induced proinflammatory cytokines and attenuated sepsis severity as evaluated by mortality, organ injury, serum LPS, and post-sepsis serum cytokines.
Chemical properties
Technical inquiry about: TM-T9543 Syk Inhibitor II hydrochloride
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