Siglec-E Protein, Mouse, Recombinant (hFc)
Ref. TM-TMPJ-01187
| 1mg | 3,029.00 € | ||
| 10µg | 139.00 € | ||
| 50µg | 404.00 € | ||
| 500µg | 2,013.00 € |
Product Information
- SiglecE, Siglec-E
Siglecs are sialic acid specific I-type lectins that are characterized by an extracellular domain (ECD) with an N-terminal Ig-like V-set domain followed by varying numbers of Ig-like C2-set domains. Mouse Siglec-E, also known as Myeloid Inhibitory Siglec (MIS), is an 80 - 85 kDa member of the CD33-related subfamily of Siglecs. Rodent and primate Siglec gene families have significantly diverged, and Siglec-9 is the most likely human ortholog of mouse Siglec-E. Siglec-E is expressed as a heavily N-glycosylated disulfide-linked homodimer and shows binding preference for disialic acids in the alpha 2-8 linkage. Siglec-E is up-regulated and additionally phosphorylated following cellular stimulation by a variety of TLR agonists. Siglec-E signaling negatively regulates the LPS-induced production of TNF- alpha and IL-6 by macrophages. Its up-regulation in macrophages parallels the development of endotoxin tolerance. Siglec-E recognition of sialylated determinants on virulent T. cruzi contributes to the suppression of dendritic cell IL-12 p40 production.
Chemical properties
Technical inquiry about: TM-TMPJ-01187 Siglec-E Protein, Mouse, Recombinant (hFc)
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