Alkaline phosphatase Protein, Human, Recombinant (hFc)
Ref. TM-TMPY-02713
50µg | 591.00 € |
Product Information
- alkaline phosphatase, intestinal, IAP
ALPI encodes for intestinal phosphatase alkaline, a brush border metalloenzyme that hydrolyses phosphate from the lipid A moiety of lipopolysaccharides and thereby drastically reduces Toll-like receptor 4 agonist activity. ALPI mutations impaired either stability or catalytic activity of ALPI and rendered it unable to detoxify lipopolysaccharide-dependent signalling. ALPI mutations should be included in screening for monogenic causes of inflammatory bowel diseases and lay the groundwork for ALPI-based treatments in intestinal inflammatory disorders.
Chemical properties
Technical inquiry about: TM-TMPY-02713 Alkaline phosphatase Protein, Human, Recombinant (hFc)
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