Integrin alpha V beta 8 Protein, Human, Recombinant (His)
Ref. TM-TMPY-05717
| 100µg | 508.00 € | ||
| 200µg | 896.00 € | ||
| 500µg | 1,834.00 € |
Product Information
- Integrin alpha V β8, Integrin α V β 8
Integrin alpha V beta 8 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. ITGAVB8 does not appear to assume different activation states; and the cytoplasmic tail does not connect to the cytoskeleton. It binds ligands containing an RGD motif; including vitronectin; fibrin and the latency associated peptide (LAP) of the latent TGF-beta complex. High affinity binding of alpha V beta 8 to LAP allows proteolytic cleavage by MT1-MMP; which releases active TGF-beta. This mechanism differs from that of alpha V beta 6; the other alpha V integrin which can activate TGF-beta from latency through non-proteolytic mechanisms.
Chemical properties
Technical inquiry about: TM-TMPY-05717 Integrin alpha V beta 8 Protein, Human, Recombinant (His)
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