Estimated delivery in United States, on Wednesday 29 May 2024
Product Information
Name:
ABT 263
Synonyms:
- 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]benzamide
- Navitoclax
- A 855071.0
- Abt-263
- Benzamide, 4-[4-[[2-(4-chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(4-morpholinyl)-1-[(phenylthio)methyl]propyl]amino]-3-[(trifluoromethyl)sulfonyl]phenyl]sulfonyl]-
CAS:
Description:
Applications A novel inhibitor of antiapoptotic BCL-2 proteins; a new promising anticancer drug candidate. Potent Bcl-2 family inhibitor.
References Adams, J., et al.: Science, 281, 1322 (1998), Degterev, A., et al.: Nat. Cell. Biol., 3, 173 (2001), Kitada, S., et al.: J. Med. Chem., 46, 4259 (2003), Danial, N., et al.: Clin. Cancer Res., 13, 7254 (2007),
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
974.61
Formula:
C47H55ClF3N5O6S3
Color/Form:
White to Pale Brown Solid
InChI:
InChI=1S/C47H55ClF3N5O6S3/c1-46(2)20-18-42(34-8-12-37(48)13-9-34)36(31-46)32-55-22-24-56(25-23-55)39-14-10-35(11-15-39)45(57)53-65(60,61)41-16-17-43(44(30-41)64(58,59)47(49,50)51)52-38(19-21-54-26-28-62-29-27-54)33-63-40-6-4-3-5-7-40/h3-17,30,38,52H,18-29,31-33H2,1-2H3,(H,53,57)/t38-/m1/s1
InChI key:
InChIKey=JLYAXFNOILIKPP-KXQOOQHDSA-N
SMILES:
CC1(C)CCC(c2ccc(Cl)cc2)=C(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc5ccccc5)c(S(=O)(=O)C(F)(F)F)c4)cc3)CC2)C1
MDL:
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EINECS:
Merck:
HS code:
Technical inquiry about: TR-A112500 ABT 263
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