Product Information
Name:
3-Acetylaminophthalic Anhydride
Synonyms:
- 3-Acetamidophthalic Anhydride
- 3-Acetamidophthalic anhydride
- NSC 16261
- NSC 17048
- acetamide, N-(1,3-dihydro-1,3-dioxo-4-isobenzofuranyl)-
- 1,3-Dioxo-2-isoindolineacetic acid
Description:
Impurity Apremilast Impurity 2
Stability Moisture Sensitive
Applications 3-Acetylaminophthalic Anhydride is used in the synthesis of Apremilast, a potent phosphodiesterase 4 and tumor necrosis Factor-α inhibitor used in the treatment of psoriatic arthritis. Also a reagent in the preparation of Tillivalline. Apremilast Impurity 2
References Man, H. et al.: J. Med. Chem., 52, 1522 (2009); Nagasaka, T. et al.: J. Org. Chem., 63, 697 (1998);
Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
205.17
Formula:
C10H7NO4
Color/Form:
Off-White to Pale Yellow Solid
InChI:
InChI=1S/C10H7NO4/c1-5(12)11-7-4-2-3-6-8(7)10(14)15-9(6)13/h2-4H,1H3,(H,11,12)
InChI key:
InChIKey=PAUAJOABXCGLCN-UHFFFAOYSA-N
SMILES:
CC(=O)Nc1cccc2c1C(=O)OC2=O
MDL:
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HS code:
