N-Acetyl-D-serine

CAS: 152612-69-6

Ref. TR-A178340

Product Information

• Name: N-Acetyl-D-serine
• Synonyms: (R)-(+)-2-(N-Acetylamino)-3-hydroxypropanoic Acid, (2R)-2-Acetamido-3-hydroxypropanoic acid, (R)-(+)-2-(N-Acetylamino)-3-hydroxypropanoic acid, <span class="text-smallcaps">D</span>-Serine, N-acetyl-, Acetyl-D-serine, D-serine, N-acetyl-, N-Acetyl-<span class="text-smallcaps">D</span>-serine

Description

Applications N-Acetyl-D-serine is the modified amino acid D-Serine (S270975). D-Serine is a neurotransmitter that is concentrated in the mammalian brain, and is one of the very few amino acids that occur in the D- and L-configurations in significant amounts. D-Serine is an potent agonist of the N-methyl-D-aspartate (NMDA) receptor in the brain, which is associated with schizophrenia. Use of D-Serine has been considered as an additional therapy for refractory schizophrenic patients.
References Heresco-Levy, U., et al.: Biol. Psych., 57, 577 (2005); Mothet, J., et al.: Proc. Nat. Acad. Sci., 97, 4926 (2000); Snyder, S. & Kim, P.: Neurochem. Res., 25, 553 (2000); Tsai, G., et al.: Biol. Psych., 44, 1081 (1998)

• Brand: TRC

Chemical properties

• Molecular weight: 147.13
• Formula: C₅H₉NO₄
• Color/Form: Neat
• InChI: InChI=1S/C5H9NO4/c1-3(8)6-4(2-7)5(9)10/h4,7H,2H2,1H3,(H,6,8)(H,9,10)/t4-/m1/s1
• InChI key: InChIKey=JJIHLJJYMXLCOY-SCSAIBSYSA-N
• SMILES: CC(=O)N[C@H](CO)C(=O)O