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Product Information
Name:
Ac-LEHD-AFC Trifluoroacetic Acid Salt
Synonyms:
- Ac-LEHD-AFC (trifluoroacetate salt)
- -a-Asparagine
- N-acetyl-L-leucyl-L-a-glutamyl-L-histidyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-
- compd. with 2,2,2-trifluoroacetic acid
- N-Acetyl-Leu-Glu-His-Asp 7-Amido-4-Trifluoromethylcoumarin
- N-Acetyl-Leu-Glu-His-Asp-(7-Amino-4-Trifluoromethylcoumarin)
- N-Acetyl-Leu-Glu-His-Asp-7-Amino-4-Trifluoromethylcoumarin Afc
- Ac-Leu-Glu-His-Asp-7-Amino-4-Trifluoro-Methylcoumarin
- Ac-Leu-Glu-His-Asp-Afc
- Ac-Lehd-Afc
- See more synonyms
- Caspase-9 Substrate I, Fluorogenic
- Caspase 9 Substrate 1F, Fluorogenic
CAS:
Description:
Applications Ac-LEHD-AFC Trifluoroacetic Acid Salt is a fluorogenic substrate that is cleaved by caspases (4,5 and 9). This activity is quantified by fluorescent detection of free AFC. Caspase-9 activation is critical for intrinsic cell death.
References Yin, Q. et al.: Mol. Cell., 22, 259 (2006); Kyewhan, P. et al.: Biochem. Biophys. Res. Comm., 347, 941 (2006);
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
765.69 + x(114.02)
Formula:
C33H38F3N7O11•x(CHF3O2)
Color/Form:
White Solid
InChI:
InChI=1S/C33H38F3N7O11.C2HF3O2/c1-15(2)8-22(39-16(3)44)31(52)41-21(6-7-26(45)46)29(50)42-23(9-18-13-37-14-38-18)32(53)43-24(12-27(47)48)30(51)40-17-4-5-19-20(33(34,35)36)11-28(49)54-25(19)10-17;3-2(4,5)1(6)7/h4-5,10-11,13-15,21-24H,6-9,12H2,1-3H3,(H,37,38)(H,39,44)(H,40,51)(H,41,52)(H,42,50)(H,43,53)(H,45,46)(H,47,48);(H,6,7)/t21-,22-,23-,24-;/m0./s1
InChI key:
InChIKey=WUAXWQRULBZETB-UHFFFAOYSA-N
SMILES:
COc1ccc(CC(=O)O)cc1OC
MDL:
Melting point:
Boiling point:
Flash point:
Density:
Concentration:
EINECS:
Merck:
HS code:
Technical inquiry about: TR-A190170 Ac-LEHD-AFC Trifluoroacetic Acid Salt
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