S-(5'-Adenosyl)-L-methionine Disulfate Salt (Synthetic)(Mixture of Diastereomers)

CAS: 24346-00-7 485-80-3

Ref. TR-A291530

Product Information

• Name: S-(5'-Adenosyl)-L-methionine Disulfate Salt (Synthetic)(Mixture of Diastereomers)
• Synonyms: 5'-[[(3S)-3-Amino-3-carboxypropyl]methylsulfonio]-5'-deoxyadenosine Disulfate, 5'-[(L-3-Amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine Disulfate, S-Adenosylmethionine Disulfate, Active Methionine Disulfate, Ademetionine Disulfate, L-S-Adenosylmethionin Disulfate, S-Adenosyl-L-methionine Disulfate

Description

Stability Hygroscopic
Applications Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.
References Friedel, H., et al.: Drugs, 38, 389 (1989), Lu, S., et al.: Int. J. Biochem. Cell Biol., 32, 391 (2000), Amin, K., et al.: Pharm. Res., 18, 914 (2001),

• Brand: TRC

Chemical properties

• Molecular weight: 594.59
• Formula: C₁₅H₂₆N₆O₁₃S
• Purity: >85%
• Color/Form: Light Beige Solid
• InChI: InChI=1S/C15H22N6O5S.2H2O4S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21;2*1-5(2,3)4/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25);2*(H2,1,2,3,4)/t7-,8+,10?,11-,14+,27?;;/m0../s1
• SMILES: C[S+](CC[C@H](N)C(=O)O)C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C(O)C1O.O=S(=O)(O)O.O=[SH](=O)O[O-]