Product Information
- N-Acetyl-L-phenylalanyl-L-α-glutamyl-L-tryptophyl-L-threonyl-L-prolylglycyl-L-tryptophyl-L-tyrosyl-L-glutaminyl-(2S)-2-azetidinecarbonyl-L-tyrosyl-L-alanyl-L-leucyl-L-prolyl-L-Leucinamide
- 1:PN: WO2009046859 PAGE: 98 claimed protein
- Af 12198
Applications AF 12198 is a peptide that selectively binds Interleukin-1 (IL-1) receptor and blocks in vivo responses to IL-1 (1). The interleukin-1 receptor can activate the innate immune response by binding to cytokines (2). Dysregulation of cytokine production can lead to aberrant immune cells activation that could result in auto-inflammatory disorders.
References (1) Akeson, A., et al.: J. Biol. Chem. (1996) 271, 30517-23(2) Yang, C. Y.: PLoS One (2015) 10:e0118671