Estimated delivery in United States, on Tuesday 21 May 2024
Product Information
Name:
Afatinib Dimaleate
Controlled Product
Synonyms:
- (2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide (2Z)-2-butenedioate (1:2) (9CI)
- BIBW 2992MA2
- 2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-, (2E)-, (2Z)-2-butenedioate (1:2)
- BIBW2992 DiMaleate
- Bibw 2992Ma2
- Bibw2992-Ma2
CAS:
Description:
Applications Afatinib Dimaleate is a salt of Afatinib {BIBW 2992) (B377000), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder. An anilino-quinazoline that irreversibly inhibits EGFR and HER2 kinase activity.
References D, Li. et al.: Oncogene., 27, 4702 (2008); Wang, X. et al.: Cancer Res., 74, 4431 (2014);
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
718.08
Formula:
C24H25ClFN5O3C4H4O4
Color/Form:
White to Pale Yellow Solid
InChI:
, /m0../s1, 2*5-3(6)1-2-4(7)8/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29), 2*1-2H,(H,5,6)(H,7,8)/b4-3+, 2*2-1-/t16-, InChI=1S/C24H25ClFN5O3.2C4H4O4/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15
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HS code:
Technical inquiry about: TR-A355315 Afatinib Dimaleate
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