Alclometasone 17,21-Dipropionate

CAS: 66734-13-2

Ref. TR-A514580

Product Information

• Name: Alclometasone 17,21-Dipropionate
• Synonyms: (7α,11β,16α)-7-Chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione, Aclovate, Alclometasone dipropionate, Almeta, Delonal, Sch 22219, Vaderm, (7Alpha,11Beta,16Alpha)-7-Chloro-11-Hydroxy-16-Methyl-3,20-Dioxopregna-1,4-Diene-17,21-Diyl Dipropanoate, (7Alpha,8Xi,9Xi,10Xi,13Xi,16Alpha)-7-Chloro-11-Hydroxy-16-Methyl-3,20-Dioxopregna-1,4-Diene-17,21-Diyl Dipropanoate, 17,21-Di(Propionate) De 7Α-Chloro-11Β,17,21-Trihydroxy-16Α-Methylpregna-1,4-Diene-3,20-Dione, 17,21-Di(Propionato) De 7Α-Cloro-11Β,17,21-Trihidroxi-16Α-Metilpregna-1,4-Dieno-3,20-Diona, 7Α-Chloro-11Β,17,21-Trihydroxy-16Α-Methylpregna-1,4-Diene-3,20-Dione 17,21-Di(Propionate), 7α-Chlor-11β,17,21-trihydroxy-16α-methylpregna-1,4-dien-3,20-dion-17,21-di(propionat), Alclometasone Dipropionate, Alclometasone-17,21-Dipropionate, Pregna-1,4-diene-3,20-dione, 7-chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)-, (7α,11β,16α)-
• CAS: 66734-13-2

Description

Applications Alclometasone-17,21-dipropionate is an synthetic glucocorticoid steroid used for inflammatory skin conditions. Alclometasone-17,21-dipropionate is topically used in dermatology as an anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent.
References Teraki, Y., et al.: Dermatol., 224, 309 (2012); Yamamoto, Y., et al.: int. J. Pharma., 426. 54 (2012); Aggerwal, A., et al.: J. Int. Med. Res., 10, 414 (1982);

• Brand: TRC

Chemical properties

• Molecular weight: 521.04
• Formula: C₂₈H₃₇ClO₇
• Color/Form: White to Off-White Solid
• InChI: InChI=1S/C28H37ClO7/c1-6-22(33)35-14-21(32)28(36-23(34)7-2)15(3)10-18-24-19(29)12-16-11-17(30)8-9-26(16,4)25(24)20(31)13-27(18,28)5/h8-9,11,15,18-20,24-25,31H,6-7,10,12-14H2,1-5H3/t15-,18+,19-,20+,24-,25+,26+,27+,28+/m1/s1
• InChI key: InChIKey=DJHCCTTVDRAMEH-DUUJBDRPSA-N
• SMILES: CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@H](C)C[C@H]2[C@H]3[C@H]([C@@H](O)C[C@@]21C)[C@@]1(C)C=CC(=O)C=C1C[C@H]3Cl