(+/-)Amethopterin

CAS: 60388-53-6

Ref. TR-A576403

Product Information

• Name: (+/-)Amethopterin
• Synonyms: N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]glutamic Acid, (±)-Methotrexate, DL-Amethopterin, DL-Methotrexate, NSC 117356, (Plus-Minus)-Amethopterin, 2-[[4-[(2,4-Diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]pentanedioic acid, <span class="text-smallcaps">DL</span>-Amethopterin, <span class="text-smallcaps">DL</span>-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, <span class="text-smallcaps">DL</span>-Methotrexate, DL-4-Amino-N10-methylpteroylglutamic acid, Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]glutamic acid

Description

Applications (+/-)Amethopterin is a folic acid antagonist and anticancer agent.
References Sharif, K.A., et al.: Biochem. Pharmacol., 55, 1683-1689 (1998); Jansen, G., et al.: Adv. Enzyme Regul., 37, 59-76 (1997);

• Brand: TRC

Chemical properties

• Molecular weight: 454.439
• Formula: C₂₀H₂₂N₈O₅
• InChI: InChI=1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)
• InChI key: InChIKey=FBOZXECLQNJBKD-UHFFFAOYSA-N
• SMILES: CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc1