Amikacin

CAS: 37517-28-5

Ref. TR-A578490

Product Information

• Name: Amikacin
• Synonyms: 6-O-(3-Amino-3-deoxy-α-d-glucopyranosyl)-4-O-(6-amino-6-deoxy-α-d-glucopyranosyl)-1-N-[(2S)-4-amino-2-hydroxybutanoyl]-2-deoxy-d-streptamine, (2R)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-[(6-amino-6-deoxy-alpha-D-glucopyranosyl)oxy]-2-{[(2xi)-3-amino-3-deoxy-alpha-D-arabino-hexopyranosyl]oxy}-3-hydroxycyclohexyl]-2-hydroxybutanamide disulfate (salt), (2S)-4-amino-N-{(1R,2S,3S,4R,5S)-5-amino-2-[(3-amino-3-deoxy-alpha-D-glucopyranosyl)oxy]-4-[(6-amino-6-deoxy-alpha-D-glucopyranosyl)oxy]-3-hydroxycyclohexyl}-2-hydroxybutanamide, (2S)-4-amino-N-{5-amino-2-[(3-amino-3-deoxyhexopyranosyl)oxy]-4-[(6-amino-6-deoxyhexopyranosyl)oxy]-3-hydroxycyclohexyl}-2-hydroxybutanamide, 1-N-(L(-)-gamma-Amino-alpha-hydroxybutyryl)kanamycin A, 1-N-[<span class="text-smallcaps">L</span>-(-)-γ-Amino-α-hydroxybutyryl]kanamycin A, 1-N-[L-(-)-γ-Amino-α-hydroxybutyryl]kanamycin A, 4-amino-N-{5-amino-2-[(3-amino-3-deoxyhexopyranosyl)oxy]-4-[(6-amino-6-deoxyhexopyranosyl)oxy]-3-hydroxycyclohexyl}-2-hydroxybutanamide, <span class="text-smallcaps">D</smallcap>-Streptamine, O-3-amino-3-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-N¹-(4-amino-2-hydroxy-1-oxobutyl)-2-deoxy-, (S)-, <span class="text-smallcaps">D</smallcap>-Streptamine, O-3-amino-3-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-<smallcap>D</span>-glucopyranosyl-(1→4)]-N¹-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-, Amicacin, Amigasol, Amiglyde-V, Amikacillin, Amikacin Inhalation Solution, Amikacin [USAN:INN:BAN], Amikacina, Amikacina [INN-Spanish], Amikacine, Amikacine [INN-French], Amikacinum, Amikacinum [INN-Latin], Amikavet, Amikozit, Amukin, Antibiotic BB-K 8, Arikace, Arikayce, Bay 41-6551, Bay 416651, Bay41-6551, Bb-K 8, D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1-4))-N(sup 1)-(4-amino-2-hydroxy-1-oxobutyl)-2-deoxy-, (S)-, D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1-6)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1-4))-N1-(4-amino-2-hydroxy-1-oxobutyl)-2-deoxy-, (S)-, D-Streptamine, O-3-amino-3-deoxy-alpha-D-glucopyranosyl-(1.fwdarw.6)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1.fwdarw.4))-N1-((2S)-4-amino-2-hydroxy-1-oxobutyl)-2-deoxy-, D-Streptamine, O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)]-N1-(4-amino-2-hydroxy-1-oxobutyl)-2-deoxy-, (S)-, D-Streptamine, O-3-amino-3-deoxy-α-D-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)]-N1-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-, Hsdb 3583, Kaminax, Lukadin, Mikavir, Nsc 177001, O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(6-amino-6-deoxy-alpha-D-glucopyranosyl-(1-6))-N(sup 3)-(4-amino-L-2-hydroxybutyryl)-2-deoxy-L-streptamine, O-3-Amino-3-deoxy-α-<span class="text-smallcaps">D</smallcap>-glucopyranosyl-(1→6)-O-[6-amino-6-deoxy-α-<smallcap>D</smallcap>-glucopyranosyl-(1→4)]-N¹-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-<smallcap>D</span>-streptamine, Pierami, Potentox, Unii-84319Sgc3C
• CAS: 37517-28-5

Description

Applications Amikacin is an antibacterial compound used in the treatment of diseases and illnesses arising from gram-negative bacterium. Antituberculosis agent.
References Villegas, M. et al.: Antimicrob. Agents Chemother., 51, 1553 (2007); Boshoff, H. et al.: J. Biol. CHem., 279, 40174 (2004);

• Brand: TRC

Chemical properties

• Molecular weight: 585.60
• Formula: C₂₂H₄₃N₅O₁₃
• Color/Form: White Solid
• InChI: InChI=1S/C22H43N5O13/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36)/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+/m0/s1
• InChI key: InChIKey=LKCWBDHBTVXHDL-RMDFUYIESA-N
• SMILES: NCC[C@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@H]1O[C@H](CO)[C@@H](O)[C@H](N)[C@H]1O