(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride
CAS: 149690-12-0
Ref. TR-A601540
1g | 513.00 € | ||
5g | 883.00 € | ||
50mg | 178.00 € |
Product Information
- (aR,?S)-?-Amino-a-methyl-[1,1'-biphenyl]-4-pentanoic Acid Ethyl Ester Hydrochloride
- [S-(R*,S*)]-?-Amino-a-methyl-[1,1'-biphenyl]-4-pentanoic Acid Ethyl Ester Hydrochloride
- Ethyl (2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-amino-2-methylpentanoate Hydrochloride
- (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methyl pentanoic acid ethyl ester hydrochloride
- (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic acid ethyl ester hydrochloride
- Ethyl (2R,4S)-5-([1,1′-biphenyl]-4-yl)-4-amino-2-methylpentanoate hydrochloride
- [1,1′-Biphenyl]-4-pentanoic acid, γ-amino-α-methyl-, ethyl ester, hydrochloride (1:1), (αR,γS)-
- [1,1′-Biphenyl]-4-pentanoic acid, γ-amino-α-methyl-, ethyl ester, hydrochloride, [S-(R*,S*)]-
Applications (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride is used as a reagent in the synthesis of LCZ696, an angiotensin II receptor and neprilysin receptor dual inhibitor. (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride is also used as a reagent in the preparation of novel NEP inhibitor prodrugs for the treatment of hypertension and cardiovascular diseases.
References Liu, M., et al.: Faming Zhuanli Shenqing. CN 105168205 A 20151223. Dec 23, 2015; Wang, Z.: PCT Int. Appl. WO 2015154673 A1 20151015. Oct 15, 2015
Chemical properties
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