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(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride
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(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride

CAS: 149690-12-0

Ref. TR-A601540

1g
513.00 €
5g
883.00 €
50mg
178.00 €
Estimated delivery in United States, on Tuesday 17 Dec 2024

Product Information

Name:
(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride
Controlled Product
Synonyms:
  • (aR,?S)-?-Amino-a-methyl-[1,1'-biphenyl]-4-pentanoic Acid Ethyl Ester Hydrochloride
  • [S-(R*,S*)]-?-Amino-a-methyl-[1,1'-biphenyl]-4-pentanoic Acid Ethyl Ester Hydrochloride
  • Ethyl (2R,4S)-5-([1,1'-Biphenyl]-4-yl)-4-amino-2-methylpentanoate Hydrochloride
  • (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methyl pentanoic acid ethyl ester hydrochloride
  • (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic acid ethyl ester hydrochloride
  • Ethyl (2R,4S)-5-([1,1′-biphenyl]-4-yl)-4-amino-2-methylpentanoate hydrochloride
  • [1,1′-Biphenyl]-4-pentanoic acid, γ-amino-α-methyl-, ethyl ester, hydrochloride (1:1), (αR,γS)-
  • [1,1′-Biphenyl]-4-pentanoic acid, γ-amino-α-methyl-, ethyl ester, hydrochloride, [S-(R*,S*)]-
Description:

Applications (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride is used as a reagent in the synthesis of LCZ696, an angiotensin II receptor and neprilysin receptor dual inhibitor. (2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic Acid Ethyl Ester Hydrochloride is also used as a reagent in the preparation of novel NEP inhibitor prodrugs for the treatment of hypertension and cardiovascular diseases.
References Liu, M., et al.: Faming Zhuanli Shenqing. CN 105168205 A 20151223. Dec 23, 2015; Wang, Z.: PCT Int. Appl. WO 2015154673 A1 20151015. Oct 15, 2015

Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
TRC
Long term storage:
Notes:

Chemical properties

Molecular weight:
384.34
Formula:
C20H25NO2·HCl
Color/Form:
Neat
InChI:
InChI=1S/C20H25NO2.ClH/c1-3-23-20(22)15(2)13-19(21)14-16-9-11-18(12-10-16)17-7-5-4-6-8-17;/h4-12,15,19H,3,13-14,21H2,1-2H3;1H/t15-,19+;/m1./s1
InChI key:
InChIKey=OKDSPZRSANXDRL-BEFAXECRSA-N
SMILES:
CCOC(=O)[C@H](C)C[C@H](N)Cc1ccc(-c2ccccc2)cc1.Cl
MDL:
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Hazard Info

UN Number:
EQ:
Class:
H Statements:
P Statements:
Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

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