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N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide
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N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide

CAS: 171887-03-9

Ref. TR-A604735

5g
83.00 €
10g
101.00 €
25g
211.00 €
Estimated delivery in United States, on Tuesday 7 Jan 2025

Product Information

Name:
N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide
Controlled Product
Synonyms:
  • 2506U90
  • Abacavir related
  • GW 282348X
  • GW 282349X
  • GR 90352X
  • 1518U91
  • 2506U90
  • 5771W93
  • 234W93
  • 26U90 Test Mix 1
  • See more synonyms
  • 1518U91
  • 2,5-Diamino-4,6-DichloroformamidoHcl
  • 2-Amino-4,6-dichloro-5-formamidopyrimidine
  • 2-Amino-4,6-dichloro-5-pyrimidinyl formamide
  • Formamide, N-(2-amino-4,6-dichloro-5-pyrimidinyl)-
  • N-(2-Amino-4,6-Dichloro-5-Pyri
  • N-(2-Amino-4,6-Dichloropyrimidin-5-Yl) Formamide
Description:

Impurity Abacavir - In House Impurity
Applications N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide (Abacavir - In House Impurity) is an intermediate of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)

Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
TRC
Long term storage:
Notes:

Chemical properties

Molecular weight:
207.02
Formula:
C5H4Cl2N4O
Color/Form:
Off-White To Beige
InChI:
InChI=1S/C5H4Cl2N4O/c6-3-2(9-1-12)4(7)11-5(8)10-3/h1H,(H,9,12)(H2,8,10,11)
InChI key:
InChIKey=XYWHZUCZNRMJGO-UHFFFAOYSA-N
SMILES:
N=c1nc(Cl)c(NC=O)c(Cl)[nH]1
MDL:
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EINECS:
Merck:
HS code:

Hazard Info

UN Number:
EQ:
Class:
H Statements:
P Statements:
Forbidden to fly:
Hazard Info:
Packing Group:
LQ:

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