cis-(-)-4-Amino-3-(3,4-dimethoxyphenyl)-1-methylpiperidine
CAS: 26722-58-7
Ref. TR-A605125
| 1mg | Discontinued | ||
| 5mg | Discontinued | ||
| 2500µg | Discontinued |
Product Information
Name:
cis-(-)-4-Amino-3-(3,4-dimethoxyphenyl)-1-methylpiperidine
CAS:
Description:
Applications Cis-(-)-4-Amino-3-(3,4-dimethoxyphenyl)-1-methylpiperidine is an intermediate in the synthesis of Tolafentrine (T531000), which is a dual-selective phosphodiesterase 3/4 inhibitor used in chronic experimental pulmonary hypertension.
References Huxtable, R., et al.: Pharmacol. Ther., 47, 371 (1990), Tanaka, K., et al.: Cancer Res., 55, 2927 (1995), Wagner, R., et al.: J. Pharmacol. Exp. Ther., 282, 1650 (1997), Cowan, K., et al.: Nat. Med., 6, 698 (2000), Shankavaram, U., et al.: J. Biol. Chem., 276, 19027 (2001),
Notice:
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Brand:
TRC
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Chemical properties
Molecular weight:
322.26
Formula:
C14H24Cl2N2O2
Color/Form:
White Solid
InChI:
InChI=1S/C14H22N2O2.2ClH/c1-16-7-6-12(15)11(9-16)10-4-5-13(17-2)14(8-10)18-3;;/h4-5,8,11-12H,6-7,9,15H2,1-3H3;2*1H/t11-,12-;;/m1../s1
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