(R)-2-Amino-2-[(5-fluoresceinyl)aminocarbonyl]ethyl Methanethiosulfonate, Trifluoroacetic Acid Salt

CAS: 1356019-48-1

Ref. TR-A609615

Product Information

• Name: (R)-2-Amino-2-[(5-fluoresceinyl)aminocarbonyl]ethyl Methanethiosulfonate, Trifluoroacetic Acid Salt
• Synonyms: 4-[[(2R)-2-amino-3-methylsulfonylsulfanylpropanoyl]amino]-2-(3-hydroxy-6-oxoxanthen-9-yl)benzoic acid;2,2,2-trifluoroacetic acid
• CAS: 1356019-48-1

Description

Stability Light/Moisture Sensitive; Desiccate And Store at -20°C, Hygroscopic
Applications A thiol specific fluorescent probe useful for ion channel and protein topology research. The recently available MTS-fluorophores may find application in the real-time monitoring of conformational changes, since fluorophores coupled to introduced cysteines can change their fluorescence during a conformational change. Fluorescence lifetime may also yield information regarding distances and molecular motion in a protein molecule.Fluorescence: max. Abs. 492nm; max. Em. 515nm; e x 10-3: 75
References Mannuzzu, L.M., et al.: Science, 271, 213 (1996), Goulett, C.C., et al.: JBC, 273, 45, 30012 (1998), Adams, C.M., et al.: JBC, 273, 46, 30204 (1998)

• Brand: TRC

Chemical properties

• Molecular weight: 642.58
• Formula: C₂₆H₂₁F₃N₂O₁₀S₂
• Color/Form: Neat
• InChI: InChI=1S/C24H20N2O8S2.C2HF3O2/c1-36(32,33)35-11-19(25)23(29)26-12-2-5-15(24(30)31)18(8-12)22-16-6-3-13(27)9-20(16)34-21-10-14(28)4-7-17(21)22;3-2(4,5)1(6)7/h2-10,19,27H,11,25H2,1H3,(H,26,29)(H,30,31);(H,6,7)/t19-;/m0./s1
• InChI key: InChIKey=NECZQSKRJXFCLU-FYZYNONXSA-N
• SMILES: CS(=O)(=O)SC[C@H](N)C(=O)Nc1ccc(-c2c3ccc(=O)cc-3oc3cc(O)ccc23)c(C(=O)O)c1.O=C(O)C(F)(F)F