(R,S)-a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid

CAS: 77521-29-0

Ref. TR-A611500

Product Information

• Name: (R,S)-a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
• Synonyms: 2-amino-3-(3-hydroxy-5-methyl-1,2-oxazol-4-yl)propanoic acid, (R,S)-alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, (R,S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, (RS)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, (±)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, 2-Amino-3-(3-hydroxy-5-methyl-1,2-oxazol-4-yl)propanoic acid, 2-Amino-3-(5-methyl-3-oxo-2,3-dihydro-1,2-oxazol-4-yl)propanoic acid, 2-Amino-3-(5-methyl-3-oxo-2,3-dihydroisoxazol-4-yl)propanoic acid, 3-(5-Methyl-3-Oxo-2,3-Dihydro-1,2-Oxazol-4-Yl)Alanine, 3-(5-methyl-3-oxo-2,3-dihydro-1,2-oxazol-4-yl)-L-alanine, 4-Isoxazolepropanoic acid, alpha-amino-2,3-dihydro-5-methyl-3-oxo-, 4-Isoxazolepropanoic acid, α-amino-2,3-dihydro-5-methyl-3-oxo-, <span class="text-smallcaps">D</smallcap>,<smallcap>L</span>-α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid, AMPA (pharmaceutical), D,L-alpha-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid, alpha-Amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid, alpha-Amino-2,3-dihydro-5-methyl-3-oxoisoxazolepropionic acid, alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, dl-alpha-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid, dl-α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid, gamma-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid, α-Amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid, α-Amino-2,3-dihydro-5-methyl-3-oxoisoxazole-4-propionic acid, α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionate, α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid, γ-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid

Description

Stability Hygroscopic
Applications A potent and selective agonist of the putative, excitatory neurotransmitter L-glutamic acid. AMPA does not interfere with binding sites for kainic acid in vitro, and AMPA- induced neuronal excitation is not significantly affected by NMDA antagonists.
References Krogsgaard-Larsen, et al.: Nature, 284, 64 (1980), Honore, T., et al.: J. Neurochem., 38, 173 (1982), MacDonald, J.F., et al.: Science, 253, 1132 (1991)

• Brand: TRC

Chemical properties

• Molecular weight: 186.17
• Formula: C₇H₁₀N₂O₄
• Color/Form: Neat
• InChI: InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)
• InChI key: InChIKey=UUDAMDVQRQNNHZ-UHFFFAOYSA-N
• SMILES: Cc1onc(O)c1CC(N)C(=O)O