[4-[(2-Amino-3-methyl-1-oxobutyl)amino]-2-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]-carbamic Acid 5-Thiazolylmethyl Ester

CAS: 765875-58-9

Ref. TR-A617010

Product Information

• Name: [4-[(2-Amino-3-methyl-1-oxobutyl)amino]-2-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]-carbamic Acid 5-Thiazolylmethyl Ester
• Synonyms: Thiazol-5-ylmethyl ((2S,3S,5S)-5-((S)-2-amino-3-methylbutanamido)-3-hydroxy-1,6-diphenylhexan-2-yl)carbamate, Ritonavir EP Impurity D
• CAS: 765875-58-9

Description

Impurity Ritonavir EP Impurity D
Applications [4-[(2-Amino-3-methyl-1-oxobutyl)amino]-2-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]-carbamic Acid 5-Thiazolylmethyl Ester, is an intermediate that can be used for the synthesis of Ritonavir (R535000), which is a selective HIV protease inhibitor.
References Daluge, S., et al.: Antimicrob. Agents Chemother., 38, 1590 (1994), Ammaranond, P., et al.: J. Clin. Virol., 26, 153 (2003), Harrigan, P., et al.: J. Infect. Dis., 191, 339 (2005), Miller, J., et al.: Bioorg. Med. Chem. Lett., 16, 1788(2006); Kempf, D., et al.: J. Med. Chem., 41, 602 (1998),

• Brand: TRC

Chemical properties

• Molecular weight: 524.68
• Formula: C₂₈H₃₆N₄O₄S
• Color/Form: Neat
• InChI: InChI=1S/C28H36N4O4S/c1-19(2)26(29)27(34)31-22(13-20-9-5-3-6-10-20)15-25(33)24(14-21-11-7-4-8-12-21)32-28(35)36-17-23-16-30-18-37-23/h3-12,16,18-19,22,24-26,33H,13-15,17,29H2,1-2H3,(H,31,34)(H,32,35)/t22-,24-,25-,26-/m0/s1
• InChI key: InChIKey=JJZMZBZVLFGIEU-GKXKVECMSA-N
• SMILES: CC(C)[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1cncs1