2-Amino-2-norbornanecarboxylic Acid

CAS: 20448-79-7

Ref. TR-A619050

Product Information

• Name: 2-Amino-2-norbornanecarboxylic Acid
• Synonyms: 2-Aminobicyclo[2.2.1]heptane-2-carboxylic Acid, 2-Aminonorbornane-2-carboxylic Acid, 2-Aminonorbornyl 2-carboxylic Acid, BCH, Bicyclo[2.2.1]Heptane-2-Carboxylic Acid, 2-Amino-, 2-Aminobicyclo[2.2.1]heptane-2-carboxylic acid

Description

Applications 2-Amino-2-norbornanecarboxylic Acid functions in the suppressive effect of I-type amino acid transporter 1 inhibition as therapeutic target on human esophageal squamous cell carcinoma. Also use in the design and preparation of KMH-233, selective and slowly reversible inhibitor of L-type amino acid transporter 1 (LAT1) which potentiates antiproliferative drug efficacy in cancer cells
References Ohshima, Y., et al.: Cancer Science, 107, 1499 (206); Huttunen, K. M., et al.: J. Med. Chem., 59, 5740 (2016)

• Brand: TRC

Chemical properties

• Molecular weight: 155.19
• Formula: C₈H₁₃NO₂
• Color/Form: White To Off-White
• InChI: InChI=1S/C8H13NO2/c9-8(7(10)11)4-5-1-2-6(8)3-5/h5-6H,1-4,9H2,(H,10,11)/t5-,6+,8-/m1/s1
• InChI key: InChIKey=MPUVBVXDFRDIPT-GKROBHDKSA-N
• SMILES: N[C@]1(C(=O)O)C[C@@H]2CC[C@H]1C2