Estimated delivery in United States, on Tuesday 28 May 2024
Product Information
Name:
6-Amino-4-(4-phenoxyphenylethylamino)quinazoline
Controlled Product
Synonyms:
- N4-[2-(4-Phenoxyphenyl)ethyl]-4,6-quinazolinediamine
- QNZ
- 4,6-quinazolinediamine, N~4~-[2-(4-phenoxyphenyl)ethyl]-
CAS:
Description:
Applications QNZ is a novel inhibitor of NFkB which displays potent inhibitory effects on both NFKB transcriptional activation (IC50=11nM) and TNF-α production (IC50=7nM). It dose-dependently inhibited carragenin-induced edema formation in the rat paw model (1mg/Kg). A useful tool to explore the role of NFkB in cellular signaling pathways.
References Tobe, M., et al.: Bioorg. Med. Chem., 11, 3869 (2003), Choi, S., et al.: J. Biol. Chem., 281, 12722 (2006)
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
356.42
Formula:
C22H20N4O
Color/Form:
Light Beige to Dark Yellow Solid
InChI:
InChI=1S/C22H20N4O/c23-17-8-11-21-20(14-17)22(26-15-25-21)24-13-12-16-6-9-19(10-7-16)27-18-4-2-1-3-5-18/h1-11,14-15H,12-13,23H2,(H,24,25,26)
InChI key:
InChIKey=IBAKVEUZKHOWNG-UHFFFAOYSA-N
SMILES:
Nc1ccc2ncnc(NCCc3ccc(Oc4ccccc4)cc3)c2c1
MDL:
Melting point:
Boiling point:
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Density:
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EINECS:
Merck:
HS code:
Technical inquiry about: TR-A621350 6-Amino-4-(4-phenoxyphenylethylamino)quinazoline
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