D-threo-(-)-2-Amino-1-(4-(nitrophenyl-d4))-1,3-propanediol

CAS: 716-61-0

Ref. TR-A622682

Product Information

• Name: D-threo-(-)-2-Amino-1-(4-(nitrophenyl-d4))-1,3-propanediol
• Synonyms: (1R,2R)-2-Amino-1-(4-(nitrophenyl-d4))propane-1,3-diol, (-)-threo-1-(p-Nitrophenyl)-2-amino-1,3-propanediol, (1R,2R)-(-)-2-Amino-1-(4-Nitrophenyl)-1,3-Propanediol, (1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-aminium, (1R,2R)-2-Amino-1-(4-Nitrophenol)Propane-1,3-Diol, (1R,2R)-2-Amino-1-(4-Nitrophenyl)Propane-1,3-Diol, (1R,2R)-threo-(-)-1-(4-Nitrophenyl)-2-amino-1,3-propanediol, 1,3-Propanediol, 2-amino-1-(4-nitrophenyl)-, (1R,2R)-, 1,3-Propanediol, 2-amino-1-(4-nitrophenyl)-, [R-(R*,R*)]-, 1,3-Propanediol, 2-amino-1-(p-nitrophenyl)-, <span class="text-smallcaps">D</span>-threo-(-)-, <span class="text-smallcaps">D</span>-(-)-threo-1-p-Nitrophenyl-2-amino-1,3-propanediol, <span class="text-smallcaps">D</span>-(-)-trans-1-p-Nitrophenyl-2-amino-1,3-propanediol, <span class="text-smallcaps">D</span>-1-(p-Nitrophenyl)-2-aminopropane-1,3-diol, <span class="text-smallcaps">D</span>-threo-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol, <span class="text-smallcaps">D</span>-threo-(1R,2R)-1-p-Nitrophenyl-2-amino-1,3-propanediol, <span class="text-smallcaps">D</span>-threo-2-Amino-1-(p-nitrophenyl)-1,3-propanediol, Amino-1-(4-nitrophenyl)propane-1,3-diol, (1R,2R)-2-, Aminonitrophenolpropanediol, Chloramphenicol D base, Chloramphenicol base, Chloramphenicol-Water Soluble, D(-)Threo-1-(4-Nitro-Phenyl)-2-Amino-1,3-Propanediol, D-(-)-Threo-2-Amino-1-(4-Nitrophenyl)-1,3-Propanediol, D-Threo-(-)-2-Amino-1-(P-Nitrophenyl)-1,3-Propanediol, L-Base, Levoamine

Description

Applications D-threo-(-)-2-Amino-1-(4-(nitrophenyl-d4))-1,3-propanediol is an intermediate in the synthesis of Chloramphenicol-d5 (C325033), the labeled analogue of Chloramphenicol (C325030), which has a broad spectrum of activity against Gram-positive and gram-negative bacteria. It is also antibacterial, and antirickettsial.
References Bartz, et al.: J. Biol. Chem., et al.: 172, 445 (1948), Gottlieb, et al.: J. Bacteriol., 55, 409 (1948), Szulczewski, D., et al.: Anal. Profiles Drug Subs., 4, 47 (1975), Price, A., et al.: J. Antibiot., 43, 118 (1981), Shalit, I., et al.: Drugs, 28, 281 (1984),

• Brand: TRC

Chemical properties

• Molecular weight: 216.227
• Formula: C₉D₄H₈N₂O₄
• Color/Form: Neat
• InChI: InChI=1S/C9H12N2O4/c10-8(5-12)9(13)6-1-3-7(4-2-6)11(14)15/h1-4,8-9,12-13H,5,10H2/t8-,9-/m1/s1/i1D,2D,3D,4D
• SMILES: [2H]c1c([2H])c([N+](=O)[O-])c([2H])c([2H])c1[C@@H](O)[C@H](N)CO