Amylin TFA salt (human)

CAS: 106602-62-4 118068-30-7 135702-23-7

Ref. TR-A636535

Product Information

• Name: Amylin TFA salt (human)
• Synonyms: AC 001, Amlintide, Human IAPP, Human amylin, Human islet amyloid peptide, Human islet amyloid polypeptide, Human islet amyloid polypeptide-NH2, Islet amyloid polypeptide TFA salt (human),L-​Lysyl-​L-​cysteinyl-​L-​asparaginyl-​L-​threonyl-​L-​alanyl-​L-​threonyl-​L-​cysteinyl-​L-​alanyl-​L-​threonyl-​L-​glutaminyl-​L-​arginyl-​L-​leucyl-​L-​alanyl-​L-​asparaginyl-​L-​phenylalanyl-​L-​leucyl-​L-​valyl-​L-​histidyl-​L-​seryl-​L-​seryl-​L-​asparaginyl-​L-​asparaginyl-​L-​phenylalanylglycyl-​L-​alanyl-​L-​isoleucyl-​L-​leucyl-​L-​seryl-​L-​seryl-​L-​threonyl-​L-​asparaginyl-​L-​valylglycyl-​L-​seryl-​L-​asparaginyl-​L-​threonyl-​, cyclic (2→7)​-​disulfideL-​Tyrosinamide

Description

Applications Amylin (human) is a hormone coexpressed with insulin by pancreatic β-cells. It is used to study the mechanisms of amyloid deposition and its role in molecular misfolding processes expecially in conditions such as diabetes type II.
References Dore, S., et al.: proc. Nat. Acad. Sci., 94, 4772 (1997); Goldsbury, C., et al.: J. Struct. Biol., 119, 17 (1997)

• Brand: TRC

Chemical properties

• Molecular weight: 4018.29
• Formula: C₁₆₅H₂₆₁N₅₁O₅₅S₂·xC₂HF₃O₂)
• Color/Form: White Solid
• InChI: InChI=1S/C165H260N50O56S2.C2HF3O2/c1-22-75(12)124(158(264)198-94(47-71(4)5)139(245)202-108(64-218)152(258)205-110(66-220)153(259)215-128(83(20)224)161(267)200-104(58-119(174)233)146(252)208-122(73(8)9)156(262)180-61-121(235)186-106(62-216)149(255)196-102(56-117(172)231)147(253)214-129(84(21)225)162(268)201-105(164(270)271)51-87-38-40-89(226)41-39-87)210-131(237)76(13)182-120(234)60-179-135(241)96(49-85-32-25-23-26-33-85)192-143(249)100(54-115(170)229)194-144(250)101(55-116(171)230)195-150(256)107(63-217)204-151(257)109(65-219)203-141(247)98(52-88-59-177-69-181-88)199-157(263)123(74(10)11)209-145(251)95(48-72(6)7)191-140(246)97(50-86-34-27-24-28-35-86)193-142(248)99(53-114(169)228)189-130(236)77(14)183-138(244)93(46-70(2)3)190-136(242)91(37-31-45-178-165(175)176)187-137(243)92(42-43-113(168)227)188-160(266)126(81(18)222)211-132(238)78(15)184-154(260)111-67-272-273-68-112(206-134(240)90(167)36-29-30-44-166)155(261)197-103(57-118(173)232)148(254)213-125(80(17)221)159(265)185-79(16)133(239)212-127(82(19)223)163(269)207-111;3-2(4,5)1(6)7/h23-28,32-35,38-41,59,69-84,90-112,122-129,216-226H,22,29-31,36-37,42-58,60-68,166-167H2,1-21H3,(H2,168,227)(H2,169,228)(H2,170,229)(H2,171,230)(H2,172,231)(H2,173,232)(H2,174,233)(H,177,181)(H,179,241)(H,180,262)(H,182,234)(H,183,244)(H,184,260)(H,185,265)(H,186,235)(H,187,243)(H,188,266)(H,189,236)(H,190,242)(H,191,246)(H,192,249)(H,193,248)(H,194,250)(H,195,256)(H,196,255)(H,197,261)(H,198,264)(H,199,263)(H,200,267)(H,201,268)(H,202,245)(H,203,247)(H,204,257)(H,205,258)(H,206,240)(H,207,269)(H,208,252)(H,209,251)(H,210,237)(H,211,238)(H,212,239)(H,213,254)(H,214,253)(H,215,259)(H,270,271)(H4,175,176,178);(H,6,7)/t75-,76-,77-,78-,79-,80+,81+,82+,83+,84+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,122-,123-,124-,125-,126-,127-,128-,129-;/m0./s1
• InChI key: InChIKey=HPYLYODKLGEPPX-NDEPHWFRSA-N
• SMILES: O=C(CC[C@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O)NCCNc1cccc2c(S(=O)(=O)O)cccc12