Product Information
- 2',3',5'-Triacetate-4-amino-1-ß-D-ribofuranosyl-s-triazin-2(1H)-one,2',3',5'-Triacetyl-5-azacytidine
- NSC 291930
- 4-Amino-1-(2,3,5-tri-O-acetyl-ß-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one
- 4-amino-1-(2,3,5-tri-O-acetylpentofuranosyl)-1,3,5-triazin-2(1H)-one
- 1,3,5-Triazin-2(1H)-one, 4-amino-1-(2,3,5-tri-O-acetyl-b-D-ribofuranosyl)-
- 2',3',5'-triacetyl-5-Azacytosine
Applications 5-Azacytidine 2’,3’5’-O-triacetate is a useful compound for the treatment and prevention of cancer and disorders related to abnormal cell proliferation, hematological disorders, and myelodysplastic syndromes (MDS). It can be also used to synthesize 2'3'5'triacetyl-5-azacytidine which is a prodrug for azacitidine. Azacitidine is a FDA-appproved DNA metnyltransferase (DNMT) inhibitor.
References Rajendiran, C., et al.: PCT Int. Appl. WO 2012135405 A1 20121004 (2012); Ziemba, A., et al.: Chemother Res Pract 965826, 9 (2011); Beisler, J. A., et al.: J. Carbohyd. Chem 4, 281 (1977)
Chemical properties
Technical inquiry about: TR-A796030 5-Azacytidine 2’,3’5’-O-triacetate
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