6-Bromo-3-hydroxypyrazine-2-carboxamide

CAS: 259793-88-9

Ref. TR-B103355

Product Information

• Name: 6-Bromo-3-hydroxypyrazine-2-carboxamide
• Synonyms: 2-Pyrazinecarboxamide, 6-bromo-3,4-dihydro-3-oxo- (ACI), 6-Bromo-3,4-dihydro-3-oxo-2-pyrazinecarboxamide (ACI), Pyrazinecarboxamide, 6-bromo-3,4-dihydro-3-oxo- (9CI), Br-T-705, 2-Pyrazinecarboxamide, 6-Bromo-3,4-Dihydro-3-Oxo-, Pyrazinecarboxamide, 6-Bromo-3,4-Dihydro-3-Oxo- (9Ci), 6-Bromo-3-Hydroxypyrazine-2-Carboxamide

Description

Applications 6-Bromo-3-hydroxypyrazine-2-carboxamide is a building block related to Favipiravir(F103350). Favipiravir is used for the treatment of advanced Ebola virus infection in a small animal model. Favipiravir suppressed the replication of Zaire Ebola virus and prevented a lethal outcome in 100% of the animals. Based on the studies, Favipiravir can be a candidate for the treatment of Ebola hemorrhagic fever.
References Oestereich, L., et al.: Antiviral Res., 105, 17 (2014); Baranovich, T., et al.: J. Virol. 87, 3741 (2013); Chem. and Eng. News p.8, Dec. 1 (2014)

• Brand: TRC

Chemical properties

• Molecular weight: 218.008
• Formula: C₅H₄BrN₃O₂
• Color/Form: Yellow Solid
• InChI: InChI=1S/C5H4BrN3O2/c6-2-1-8-5(11)3(9-2)4(7)10/h1H,(H2,7,10)(H,8,11)
• InChI key: InChIKey=KZBREXQQUFIWKD-UHFFFAOYSA-N
• SMILES: NC(=O)c1nc(Br)c[nH]c1=O