Bardoxolone

CAS: 218600-44-3

Ref. TR-B118660

Product Information

• Name: Bardoxolone
• Synonyms: CDDO, RTA 401, 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic Acid, 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic acid
• CAS: 218600-44-3

Description

Applications Bardoxolone is a synthetic oleanane triterpenoid that exerts multifunctional activities in the control of cellular growth and differentiation. Bardoxolone is capable of activating the transcription factor peroxisome proliferator activator receptor-γ (PPARγ), its apoptotic effects in malignant cells have been shown to occur independently of PPARγ. Bardoxolone was developed as an potential drug for the improvement of hyperglycemia, proteinuria, glomerulus structure, serum creatine, which may in turn be beneficial to treat diabetic kidney diseases, cancer and thromboembolic events.
References Shepler, B., et al.: Clinical. Therap., 34, 1237 (2012); Speranza, G., et al.: Cancer. Chemo. Pharmacol., 69, 431 (2012); Sporn, M.B., et al.: J. Natural. Prod., 74, 537 (2011);

• Brand: TRC

Chemical properties

• Molecular weight: 491.66
• Formula: C₃₁H₄₁NO₄
• Color/Form: Off-White to Light Brown Solid
• SMILES: CC1(C)CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](C(=O)C=C4[C@@]3(C)CC[C@H]3C(C)(C)C(=O)C(C#N)=C[C@]43C)[C@@H]2C1