BAY 11-7082

CAS: 19542-67-7

Ref. TR-B118790

Product Information

• Name: BAY 11-7082
• Synonyms: (E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile, (E)-3-(p-Tolylsulfonyl)-acrylonitrile, BAY 11-7821, BAY 117821, (2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile, (2E)-3-[(4-Methylphenyl)sulfonyl]acrylonitrile, (E)-3-(4-Methylphenylsulfonyl)-2-propenenitrile, 2-Propenenitrile, 3-((4-methylphenyl)sulfonyl)-, 2-Propenenitrile, 3-[(4-methylphenyl)sulfonyl]-, (2E)-, 2-Propenenitrile, 3-[(4-methylphenyl)sulfonyl]-, (E)-, 3-((4-Methylphenyl)sulfonyl)-2-propenenitrile, 3-(p-Toluenesulfonyl)acrylonitrile, 3-(p-Tolylsulfonyl)acrylonitrile, Acrylonitrile, 3-(p-tolylsulfonyl)-, (E)-, Bay 11-7082, Bay 11-7821, Bay 117821

Description

Applications BAY 11-7082 is a nuclear factor-κB (NF-κB) inhibitor and a potential anti-inflammatory agent. It selectively and irreversibly inhibits NF-κB activation by blocking TNF-α-induced phosphorylation of Iκβα without affecting constitutive Iκβα phosphorylation. Potent IKK inhibitor
References Pierce, J.W., et al.: J. Biol. Chem., 272, 21096 (1997); Keller, S.A., et al.: Blood, 96, 2537 (2000); Remacle-Bonnet, M.M., et al.: Cancer Res., 60, 2007 (2000); Thévenod, F., et al.: J. Biol. Chem., 275, 1887 (2000); Petegnief, V., et al.: Neuroscience, 104, 223 (2001); Kauppinen, T.M., et al.: J. Immunol., 174, 2288 (2005)

• Brand: TRC

Chemical properties

• Molecular weight: 207.25
• Formula: C₁₀H₉NO₂S
• Color/Form: Neat
• InChI: InChI=1S/C10H18O/c1-5-9(4)7-10(11)6-8(2)3/h5,8-9H,1,6-7H2,2-4H3
• InChI key: InChIKey=VUSBHGLIAQXBSW-UHFFFAOYSA-N
• SMILES: C=CC(C)CC(=O)CC(C)C